A RAB6 TO RAB11 TRANSITION IS REQUIRED FOR DENSE-CORE GRANULE AND EXOSOME BIOGENESIS IN DROSOPHILA SECONDARY CELLS.

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.

Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core here granules (DCGs), which disperse when released from the cell surface.Despite the relevance of this dynamic process to diseases such as diabetes and human neurodegenerative disorders, our mechanistic understanding

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Exploring the progression of drug dependence in a methamphetamine self-administration rat model through targeted and non-targeted metabolomics analyses

Abstract Persistent neurochemical and biological disturbances resulting from repeated cycles of drug reward, withdrawal, and relapse contribute to drug dependence.Methamphetamine (MA) is read more a psychostimulant with substantial abuse potential and neurotoxic effects, primarily affecting monoamine neurotransmitter systems in the brain.In this st

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